ISBN: 978-0-6450017-9-2
Exon Publications, Brisbane, Australia

Ryszard Pluta, MD, PhD (Editor)
Laboratory of Ischemic and Neurodegenerative Brain Research, Mossakowski Medical Research Institute, Polish Academy of Sciences, Warsaw, Poland


Cerebral ischemia is one of the most common causes of dementia, which develops in more than half of patients after an ischemic episode. The main mechanism is thought to be pathological changes in the hippocampus, especially in the CA1 area, underlying episodic memory impairment, which is the earliest and most important clinical symptom of post-ischemic dementia. The 13 chapters of this book present a new picture of ischemic brain disease, synthesizing the latest data on disease mechanisms, care for patients with this disease, and potential therapeutic targets. The authors present the characteristics of cerebral ischemia from pregnancy and childhood through adolescence to adulthood. The first two chapters provide a snapshot of the anatomy of the cerebral cortex and the hippocampus, the most affected brain structures after cerebral ischemia. This is followed by nine chapters that present a comprehensive view of the pathological mechanisms of cerebral ischemia, and how a deep understanding of these pathomechanisms hold the key for the discovery and development of novel therapies to help patients affected by cerebral ischemia. Chapter 12 shares real-life experience and challenges of rehabilitating patients into the community after cerebral ischemia, and chapter 13 analyzes the social risk variations, including gender inequality, in the reintegration of post-ischemic stroke patients. Although primarily aimed at scientists and clinicians, the contents of the book will be of interest to all those who are interested in cerebral ischemia, including patients and their caregivers.

DOI: https://doi.org/10.36255/exonpublications.cerebralischemia.2021

Published: 2021-11-06


Janusz Kocki, MD, PHD

Page vii


Ryszard Pluta, MD, PHD

Pages ix-x

The Anatomy of the Cerebral Cortex

Pradip Chauhan, MBBS, MS, CRM , Ashish Rathawa, MBBS, MS , Kinjal Jethwa, MBBS, MS, Simmi Mehra, MBBS, MS

Pages 1-16

The Anatomy of the Hippocampus

Pradip Chauhan, MBBS, MS, CRM, Kinjal Jethwa, MBBS, MS , Ashish Rathawa, MBBS, MS, Girish Chauhan, BDS, MDS, Simmi Mehra, MBBS, MS

Pages 17-30

Ischemic Brain Injury in Hyperhomocysteinemia

Jan Lehotsky, PHD, DSC, Maria Kovalska, PHD , Eva Baranovicova, PHD , Petra Hnilicova, PHD , Dagmar Kalenska, PHD , Peter Kaplan, PHD

Pages 61-72

Exosomes in Post-Ischemic Brain

Ryszard Pluta, MD, PHD, Mirosław Jabłoński, MD, PHD

Pages 73-85

Neuroinflammation in Post-Ischemic Brain

Katarina Živančević, MPHARM, Darko Lović, MPHARM, Pavle R. Andjus, PHD , Lidija Radenovic, PHD

Pages 87-109

The Role of Cathepsin B in Ischemia-Reperfusion Injury After Stroke

Bhakta Prasad Gaire, PHD, Lalita Subedi, PHD, Hironori Teramoto, BSC, Bingren Hu, PHD

Pages 131-147

The Role of Curcumin in Post-Ischemic Brain

Marta Rusek, PHD, Stanislaw Czuczwar, MD, PHD

Pages 149-164

Treating Cerebral Ischemia: Novel Therapeutic Strategies from Experimental Stroke Research

Xuan Zheng, MSC , Matteo Haupt, BSC , Mathias Bähr, MD , Lars Tatenhorst, PHD , Thorsten R. Doeppner, MD, MSC

Page 165-185

Understanding Social Risk Variation Across Reintegration of Post-Ischemic Stroke Patients

Katryna Cisek, PHD, Thi Nguyet Que Nguyen, PHD, Alejandro Garcia-Rudolph, PHD , Joan Saurí, PHD, John D. Kelleher, PHD

Pages 201-219


Pages 221-224