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Urologic Cancers

Urologic cancers are an umbrella term for cancers of the prostate, kidney, bladder, penis, and testis. Routine use of advanced imaging modalities for various reasons has increased the incidental detection of some of these cancers at an early stage. Robot-assisted surgery for nephrectomy, prostatectomy, cystectomy, and retroperitoneal lymph node dissection have improved surgical outcomes of localized disease. The introduction of targeted therapies since 2006 has revolutionized the management of metastatic kidney cancer. Despite these advances, the five-year survival of patients with advanced renal cancer is still poor and we need a better understanding of the disease. The book Urologic Cancers brings together an international team of clinicians and basic scientists to provide an up-to-date overview of a wide spectrum of topics that comprise epidemiological, pathological, clinical, and biological aspects of urologic cancers. From the epidemiological spectrum, the most recent information on the epidemiology of testicular cancer and penile cancer are presented. From the clinical spectrum, the characteristics and management of divergent urothelial neoplasms, the role of surgery in the management of testicular and kidney cancer, biopsy approaches for better detection and diagnosis of prostate cancer, the role of family history and germline genetics in prostate cancer disease profiling and screening, and the need for the implementation of quality assurance programs to improve prostate cancer care discussed. The biological aspects of disease mechanisms focus on various emerging molecular pathways and how these can be targeted to develop novel therapeutics. The contents of the book will be of interest to healthcare professionals, basic scientists and clinicians interested in urologic cancers.

Urologic Cancers
ISBN: 978-0-6453320-5-6 Exon Publications, Brisbane, Australia

Neil Barber, MBBS, FRCS (Editor)
Frimley Park Hospital, Frimley Health NHS Foundation Trust, Camberley, UK

Ahmed Ali, MBCHB, MSC, FRCS (Editor)
Frimley Park Hospital, Frimley Health NHS Foundation Trust, Camberley, UK

Published: 2022-09-12

Foreword

Stephen Langley, MS, FRCS

Page vii

Preface

Neil Barber, MBBS, FRCS, Ahmed Ali, MBCHB, MSC, FRCS

Page ix

The Etiology of Bladder Cancer

Keng Ng, MBBS, PhD, FRCS

Pages 23-28

The Role of MicroRNA in the Metastatic Phenotype of Bladder Cancer

Aaron Perecman, MD, Adam Wiggins, MD, Jonathan Xu, MD, Sanjna Das, BS, Thomas Kalantzakos, BA, Travis Sullivan, MS, Kimberly Rieger-Christ, PHD

Pages 29-43

MetastamiRs in Renal Cell Carcinoma: An Overview of MicroRNA Implicated in Metastatic Kidney Cancer

Jonathan Xu, MD, Aaron Perecman, MD, Adam Wiggins, MD, Thomas Kalantzakos, BA, Sanjna Das, BS, Travis Sullivan, MS, Kimberly Rieger-Christ, PHD

Pages 71-93

New trends in robotic retroperitoneal partial nephrectomy

Mitchell Barns, MD, Sarah O'Neill, MBBS, FRACS, Neil Barber, MBBS, FRCS

Pages 95-106

Organ Sparing Surgery in Testicular Cancer

Lily Whitehurst, MBBCH, MRCS, Andrew Chetwood, MBCHB, FRCS

Pages 117-129

Prostate Cancer Diagnosis: Biopsy Approaches

Paul Gravestock, BMBS, MPhys, MRCS, Shaw Matthew, MA, BM BCh, MD, FRCS, Rajan Veeratterapillay, MBBS, FRCS, Rakesh Heer, BMBS, FRCS, PhD

Pages 141-168

Prostate Cancer: Advances in Radiation Oncology, Molecular Biology, and Future Treatment Strategies

Tao Wang, PHD, Brian Lewis, PHD, Marcus Ruscetti, PHD, Kriti Mittal, MD, MS, Ming-Jin Wang, DO, Mitchell Sokoloff, MD, Linda Ding, PHD, Maryann Bishop-Jodoin, MED, Thomas J. FitzGerald, MD

Pages 169-183

Improving Prostate Cancer Care through Quality Assurance Programs

Hans Veerman, MD, Marais Hagens, MD, André Vis, MD, PHD, Jeroen van Moorselaar, MD, PHD, Pim van Leeuwen, MD, PHD, Michel Wouters, MD, PHD, Henk van der Poel, MD, PHD

Pages 185-198

The Role of Family History and Germline Genetics in Prostate Cancer Disease Profile and Screening

Holly Ni Raghallaigh MBChB, MD, FRCS, Simon RJ Bott, MD, FRCS, FEBU

Pages 199-213

Index

Pages 215-218

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