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Ryszard Pluta, MD, PHD

Cerebral ischemia is a global public health threat and one of the important causes of mortality and loss of independence in those affected. Moreover, cerebral ischemia is one of the most common causes of dementia, which sooner or later develops in more than half of patients after an ischemic episode. This book presents a new picture of ischemic brain disease that knows no geographic boundaries and continues to attract the attention of a large community of scientists, physicians, engineers, and related health professionals by synthesizing the latest modern data on disease progression mechanisms and possible care for patients with this disease. The authors present the characteristics of cerebral ischemia from pregnancy and childhood through adolescence to adulthood. Post-ischemic brain injury in animals and humans leads to proteomic, genomic, and structural changes in various brain structures, starting in the hippocampus, showing changes identical to those seen in Alzheimer’s disease. Cerebral ischemia is the second naturally occurring disease after Alzheimer’s disease, which primarily causes the death of pyramidal neurons in the CA1 region of the hippocampus. The main pathology is considered to be post-ischemic changes in the hippocampus, especially in its CA1 area, underlying episodic memory impairment, which is the earliest and most important clinical symptom of post-ischemic dementia. CONTINUE READING…..


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