Treating Cerebral Ischemia: Novel Therapeutic Strategies from Experimental Stroke Research

Xuan Zheng, MSC; Matteo Haupt, BSC; Mathias Bähr, MD; Lars Tatenhorst, PHD; Thorsten R. Doeppner, MD, MSC

doi:10.36255/exonpublications.cerebralischemia.2021.therapy

Open access book Cerebral Ischemia cover

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Published: Nov 6, 2021

DOI: https://doi.org/10.36255/exonpublications.cerebralischemia.2021.therapy

Keywords:

cerebral ischemia, extracellular vesicles, microRNAs, neuroprotection, neurodegeneration

Xuan Zheng, MSC

Department of Neurology, University of Göttingen Medical School, Göttingen, Germany

Matteo Haupt, BSC

Department of Neurology, University of Göttingen Medical School, Göttingen, Germany

Mathias Bähr, MD

Department of Neurology, University of Göttingen Medical School, Göttingen, Germany

Lars Tatenhorst, PHD

Department of Neurology, University of Göttingen Medical School, Göttingen, Germany

Thorsten R. Doeppner, MD, MSC

Department of Neurology, University of Göttingen Medical School, Göttingen, Germany

ABSTRACT

Although systemic thrombolysis and endovascular treatment have revolutionized modern stroke treatment, the majority of patients do not qualify for either treatment paradigm. Hence, novel adjuvant therapeutic strategies are required. This chapter provides an overview of our current understanding of novel therapeutic strategies in preclinical stroke models. The chapter is organized in three major parts to cover the acute, subacute, and chronic phases of ischemic stroke. The potential of various pharmacological agents, stem cells, microRNAs, and extracellular vesicles as therapeutic avenues along with the progress and challenges are discussed.