Gastrointestinal cancers represent a heterogeneous group of diseases of the gastrointestinal tract. There is an interplay of various non-modifiable and modifiable risk factors that foster the conversion of normal cells to precursor cells, precursor cells to premalignant cells, and premalignant cells to malignant cells. Gastrointestinal cancers are diverse in etiology and clinical management. The chapters of this book explore the clinically relevant aspects of this diversity under three broad categories: epidemiology and pathology, early diagnosis and prognosis, and surgical management. The etiological aspects focus on stomach cancer while the pathological aspects provide an overview of colorectal cancer, how primary colorectal cancer becomes metastatic through epithelial mesenchymal transition, and how macrophage-derived extracellular vesicles drive tumor development and enable the progression of most gastrointestinal cancers. Chapters on early detection and prognosis emphasize on biomarker discovery, both at genetic and proteomic level, and how these can be used to effectively predict the origin, progress, prognosis, and treatment response of gastrointestinal cancers in general and pancreatic cancer in particular. Given that the gastrointestinal tract is solely responsible for the processing of the diet we consume, the impact of diet that we consume cannot be ignored. There is a dedicated chapter that covers the role of diet and lifestyle on colorectal cancer incidence and survival. Despite various treatment modalities, for localized cancers, surgery is still the best form of curative treatment, and the role of surgical management of gastrointestinal stromal tumors and esophageal cancers are elegantly summarized in two chapters. The contents of this book provide the readers with an overview of several important aspects of gastrointestinal cancers and may be of interest to healthcare professionals interested in gastrointestinal cancers.

Gastrointestinal Cancers
ISBN: 978-0-6453320-6-3, Exon Publications, Brisbane, Australia

Jose Andres Morgado-Diaz, PHD (Editor)
Cellular and Molecular Oncobiology Program, Cellular Dynamic and Structure Group, Instituto Nacional de Câncer – INCA, Rio de Janeiro, Brazil


Published: 2022-09-30


Wanderley de Souza, PHD

Page vii


Jose Andres Morgado-Diaz, PHD

Pages ix-x

Colorectal Cancer: An Overview

Baojun Duan, PHD, Yaning Zhao, MD, Jun Bai, MD, Jianhua Wang, MD, Xianglong Duan, MD, Xiaohui Luo, MD, Rong Zhang, MD, Yansong Pu, MD, Mingqing Kou, MSC, Jianyuan Lei, MSC, Shangzhen Yang, BS

Pages 1-12

Epithelial-Mesenchymal Transition in Metastatic Colorectal Cancer

Jose Morgado Diaz, PHD, Mônica Silveira Wagner, PHD, Annie C.M. Sousa-Squiavinato, PHD, Julio C.M. de Freitas-Junior, PHD, Wallace Martins de Araujo, PHD, Josiane Weber Tessmann, MSC, Murilo Ramos Rocha, PHD

Pages 25-42

Clinicopathological Features and Surgical Management of Gastrointestinal Stromal Tumors: State-of-the-Art

Alessandro Paganini, MD PHD, FACS, Silvia Quaresima, MD, PHD, Andrea Balla, MD, PHD, MSC, Livia Palmieri, MD, Diletta Corallino, MD, Salomone Di Saverio, MD, FACS, FRCS, Salvador Morales-Conde, MD, PHD

Pages 43-56

The Role of Macrophage- Derived Extracellular Vesicles in Gastrointestinal Cancers

Mariana Renovato-Martins, PHD, Aline Casimiro Gomes, PHD, Carolinne Souza Amorim, MSC, João Alfredo Moraes, PHD

Pages 57-72

Biomarkers for the Early Detection of Pancreatic Ductal Adenocarcinoma

Carl A.K. Borrebaeck, PHD, Linda D. Mellby, PHD, Thomas C. King, MD, PHD

Pages 85-100

The Epidemiology of Stomach Cancer

Luiz Claudio Santos Thuler, MD, MSC, PHD

Pages 101-110

Minimally Invasive Esophagectomy for Esophageal Cancer

Livia Palmieri, MD, Tiziano De Giacomo, MD, Silvia Quaresima, MD, Andrea Balla, MD, PHD, Daniele Diso, MD, Emilia Mottola, MD, Franco Ruberto, MD, Alessandro M. Paganini, MD, PHD, FACS

Pages 111-124


Pages 125-128