Metastasis is the dissemination of neoplastic cells from the primary tumor, and their colonization and growth in another part of the body. The process of metastasis is orchestrated by a complex network of biological events, and our understanding of the processes that regulate metastasis has significantly improved. This open access book on metastasis provides an in-depth analysis of our understanding of the molecular mechanisms, detection, and clinical management of metastatic cancer. Updates are given on molecular imaging of brain metastasis and recurrence, management of pulmonary nodules for the early diagnosis of lung cancer, surgical management of both primary and metastatic lung cancers, genomic landscapes and tumor evolution of metastatic gynecological cancers, epigenetic changes in metastatic ovarian cancer, microRNAs in metastasis of prostate cancer, hematological toxicity of radiation therapy for bone metastasis, DNA damage response in cancer metastasis, tumor endothelial cells and angiogenesis in cancer metastasis, apoptosis-induced compensatory proliferation in cancer, the potential of targeting apoptosis to overcome chemotherapy resistance, and features  of  metastatic  Ewing  sarcoma. This open access book on metastasis is aimed primarily at clinicians and scientists, but many areas will also be of interest to the layperson.

ISBN: 978-0-6453320-2-5, Exon Publications, Brisbane, Australia

Consolato M. Sergi, MD, PhD, MPH, FRCPC, FCAP (Editor)
Anatomic Pathology Division, Children’s Hospital of Eastern Ontario, ON, Canada


Published: 2022-05-03


Prof. Dr. med. David Horst

Page vii


Consolato M. Sergi, MD, PhD, MPH, FRCPC, FCAP

Pages ix-xi


Pages xiii-xvi

Molecular Imaging of Brain Metastases with PET

Harry W. Schroeder III, MD, PHD, Lance T. Hall, MD

Pages 1-16

The Use of Imaging Tests for the Diagnosis and Management of Lung Nodules

Blanca Lumbreras, PHD, Elisa Chilet-Rosell, PHD, Lucy A. Parker, PHD

Pages 17-31

The State of the Art in Thoracic Surgery: Treating Lung Cancer Between Tradition and Innovation

Giuseppe Mangiameli, MD, PHD, Ugo Cioffi, MD, PHD, Marco Alloisio, MD, Alberto Testori, MD

Pages 33-48

Pulmonary Metastases: Surgical Principles, Surgical Indications, and Innovations

Giuseppe Mangiameli, MD, PHD, Ugo Cioffi, MD, PHD, Marco Alloisio, MD, Alberto Testori, MD

Pages 49-62

Influence of Aberrant Epigenetic Changes and the Tumor Microenvironment in Ovarian Cancer Metastasis

Diego Aviles, MD, David Warshal, MD, Michelle Buchbinder, PHD, Olga Ostrovsky, PHD

Pages 77-89

MetastamiRs: The Role of MicroRNAs in the Metastatic Phenotype of Prostate Cancer

Adam Wiggins, MD, Jonathan Xu, MD, Aaron Perecman, MD, Thomas Kalantzakos, BA, Sanjna Das, BS, Travis Sullivan, MS, Kimberly Rieger-Christ, PHD

Pages 91-107

The Roles of Tumor Endothelial Cells in Cancer Metastasis

Kyoko Hida, DDSc, PhD, Nako Maishi, DDSc, PhD, Ryo Takeda, DDSc, Yasuhiro Hida, MD, PHD

Pages 137-148

Apoptosis-Induced Compensatory Proliferation in Cancer

Ulisses Moreno Celis, PHD, Teresa García-Gasca, PHD, Carmen Mejía, PHD

Pages 149-161

Targeting Apoptosis to Overcome Chemotherapy Resistance

Eda Dogan, MSC, Hale Guler Kara, PHD, Buket Kosova, PHD, Vildan Bozok Cetintas, PHD

Pages 163-180

Features of Metastatic Ewing Sarcoma

Nikolas C. Zetouni, MSC; Consolato M. Sergi, MD, PhD, FRCPC, FCAP

Pages 181-193


Pages 195-198