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Metastasis is an inherent characteristic of malignant tumors and designates the dissemination of cancer cells in the body with formation of secondary tumors at distant sites. Hematogenous metastasis marks the latest stage of tumor progression and in many cases is associated with poor clinical outcome. The biological mechanism of tumor metastasis is complex and requires several steps. Cancer cells have to infiltrate blood vessels or lymphatics, detach from the primary tumor, float to the next microcirculation, emigrate the vessel and proliferate in order to produce new tumor mass. This cellular behavior requires tight regulation on genetic and epigenetic levels that may vary from tumor to tumor due to heterogeneous genetic backgrounds but also activates conserved cellular pathways that are shared among different cancer entities. In this book, the authors cover several important clinical and biological aspects of cancer metastasis while at the same time highlighting different tumor entities. CONTINUE READING.....
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