ISBN: 978-0-6450017-4-7
Exon Publications, Brisbane, Australia

Waldemar Debinski, MD, PhD (Editor)
Brain Tumor Center of Excellence, Wake Forest
Baptist Medical Center Comprehensive Cancer Center, Winston Salem, NC, USA


Gliomas are the primary brain tumors of the central nervous system. The prognosis, especially for high-grade gliomas, is dismal; the treatment of these tumors represents an unmet need in medicine. This book, contributed by an excellent team of clinicians and basic scientists, touches upon several critical aspects of glioma research and clinical therapies. There is a considerable emphasis on translational efforts.  The 13 chapters of the book cover aspects of clinically-relevant models, glioma stem-like cells, IDH mutations, integrated approach for better patient outcome, abnormal cholesterol and other metabolic processes, bioinformatics for survival prediction, molecular signature for prognostication, neuro-functional monitoring during surgery, glioma-related epilepsy, and glioneuronal tumors along with various natural and synthetic drug candidates currently under evaluation. As such, the individual contributions provide a glimpse on the magnitude of challenges and potential solutions in a variety of research areas. This book will likely be interest to a wide audience seeking more information on challenges gliomas present to both scientists and clinicians.


Published: 2021-04-30


Anthony L. Asher

Pages vii-viii


Waldemar Debinski

Page ix

Mouse Models of Experimental Glioblastoma

Fang Jin, Helen Jin-Lee, Aaron Johnson

Pages 15-45

Cancer Stem Cells in Pediatric Brain Tumors

Miranda M Tallman, Abigail A Zalenski, Monica Venere

Pages 47-60

Emerging Roles of Wild-type and Mutant IDH1 in Growth, Metabolism and Therapeutics of Glioma

Matthew Garrett, Yuki Fujii, Natsuki Osaka, Doshun Ito, Yoshihisa Hirota, Atsuo Sasaki


Integration of Molecular Analysis, Cutting-edge Mouse Genetic Models and Proton Therapy to Improve Outcomes for Glioma Patients

Soma Sengupta, Luke Pater, Daniel Krummel, Bruce Aronow, Yoshihisa Hirota, Timothy Phoenix, Atsuo Sasaki

Pages 79-95

Cholesterol Derivatives as Promising Anticancer Agents in Glioblastoma Metabolic Therapy

Khouloud Sassi, Thomas Nury, Mohammad Samadi , Fatma Fennira, Anne Vejux , Gérard Lizard

Pages 97-119

Targeting Energy Metabolism to Overcome Therapeutic Resistance of Glioblastoma and Tumor-associated Edema

Biplab Dasgupta, Yoshihisa Hirota, Yuki Fujii, Natsuki Osaka, Doshun Ito, David Plas, Atsuo Sasaki

Pages 121-137

Therapeutic Potential of Curcumin for the Treatment of Malignant Gliomas

Blake C. Walker, Srijan Adhikari, Sandeep Mittal

Pages 139-149

Molecular Markers of Gliomas to Predict Treatment and Prognosis: Current State and Future Directions

Catarina Rapôso, João Luiz Vitorino Araújo, Natália Barreto dos Santos

Pages 171-185

Pathogenesis and Management of Brain Tumor-Related Epilepsy

Srijan Adhikari, Blake Walker, Sandeep Mittal

Pages 199-210


Pages 229-233