ISBN: 978-0-646-80968-7


Thomas Wisniewski, MD (ed)
New York University Alzheimer’s Disease Center, New York University School of Medicine, New York, USA


Alzheimer’s disease (AD) is the most common cause of dementia. With the increasing average age of humans worldwide, the total number of people with dementia is projected to reach 82 million by 2030 and 152 million by 2050. No effective pharmaceutical agents exist to halt or slow down the disease progression. Hence, there is a tremendous imperative to gain a better understanding of the pathogenesis of AD and to develop effective treatments. This book brings together an international team of experts to provide a comprehensive and up-to-date overview of AD. The most current information on several critical aspects of AD are presented, providing the readers with a broad picture of the underlying neuropathology, genetics, proteomics, risk factors, novel biomarkers, and potential interventions. Chapters 1–5 discuss the underlying AD pathogenesis using genomic and proteomic approaches, linking diverse pathways that can lead to complex metabolic dysfunction. Chapter 6 reviews the potential role of trace metals in AD, while Chapter 7 examines the diversity of Aβ species involved in AD pathology. Chapter 8 discusses the contributions of white matter degeneration in AD. Chapter 9 examines the potential intriguing role of the brain-gut-microbiota axis in mediating AD. Chapters 10 and 11 discuss potential biomarkers for AD, such as deficits in ocular exploration and early language impairments, respectively. Chapters 12–15 examine possible novel preventative and/or therapeutic methodologies such as exercise, optimizing depression therapy, and diverse psychosocial interventions. The book will be of value to clinicians and health professionals caring for patients with AD, and will provide a comprehensive and thought-provoking introduction to young investigators interested in translational aspects of the AD and related dementias.

Published: 2019-11-21


Fernando Goni

Page vii


Thomas Wisniewski

Page ix


Pages xi-xvii

Common Proteomic and Genomic Contribution to Ischemic Brain Damage and Alzheimer’s Disease

Ryszard Pluta, Marzena Ułamek-Kozioł, Sławomir Januszewski, Stanisław J. Czuczwar

Pages 53-68

Contributing Factors of Neurodegeneration in Alzheimer’s Disease

Breeya Tailor, Alexander Pilozzi, Xudong Huang

Pages 69-84

The Role of Trace Metals in Alzheimer’s Disease

Chiara A. De Benedictis, Antonietta Vilella, Andreas M. Grabrucker

Pages 85-106

Relationship between Alzheimer’s Disease and the Human Microbiome

Yusuke Fujii, Anushka Khasnobish, Hidetoshi Morita

Pages 147-158

Ocular Exploration in the Diagnosis and Follow-Up of the Alzheimer’s Dementia

Elena Salobrar-Garcia, Rosa de Hoz, Ana I. Ramírez, Juan J. Salazar, Pilar Rojas, Inés López-Cuenca, Jose Fernández-Albarral, José M. Ramírez

Pages 159-177

The Deterioration of Semantic Networks in Alzheimer’s Disease

Israel Martínez-Nicolás, Juan Carro, Thide E. Llorente, Juan José García Meilán

Pages 179-191

A Collaborative Approach to Treatment of Alzheimer’s Disease from a Psychological Perspective

Anna Maria Jadwiga Wegierek, Katarzyna Lesniak, Shan Patel, Yuliya Bogdanovskaya

Pages 237-250


Pages 251-255