ISBN: 978-0-6450017-7-8
Exon Publications, Brisbane, Australia

Toshiyuki Araki, MD, PhD (Editor)
Department of Peripheral Nervous System Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Japan

Amyotrophic lateral sclerosis is a fatal, progressive neurodegenerative disorder characterized by motor neuron cell death in the brain and spinal cord. The typical disease symptom is the rapid loss of muscle control, which eventually leads to the complete paralysis of voluntary muscles of the entire body. There is no curative treatment for amyotrophic lateral sclerosis. The rarity of the disease and the difficulties in accurate early diagnosis are the major challenges in the proper understanding of the disease and the development of curative therapy. This book brings together a team of experts, both clinicians and basic scientists, to provide a comprehensive understanding of amyotrophic lateral sclerosis, challenges, and approaches to combat this devastating disease. The clinical chapters provide excellent views of diagnosis, pathology, management, and the problem of diagnostic delay. The basic science chapters provide a comprehensive description of pathomechanisms and therapies with emphasis on dysfunctional astrocytes, impaired synaptic transmission, defective axonal transport, biomarkers, cell-based therapies, and gut microbiota. The book is primarily aimed at clinicians and basic scientists; however, it will likely be of interest to a wide audience interested in amyotrophic lateral sclerosis.


Published: 2021-07-25

Astrocytes in Amyotrophic Lateral Sclerosis

Sandra H. Vaz, PHD, Sara Pinto, MSC, Ana M. Sebastião, PHD, Dora Brites, PHD

Pages 35-53

Synaptic Transmission and Motoneuron Excitability Defects in Amyotrophic Lateral Sclerosis

Frédérique Scamps, PHD, Franck Aimond, PHD, Cécile Hilaire, PHD, Cédric Raoul, PHD

Pages 55-94

Blood-based Biomarkers for Amyotrophic Lateral Sclerosis

Heather M. Wilkins, PHD, Mazen M. Dimachkie, MD, Abdulbaki Agbas, MSC, PHD

Pages 105-120

Cell-based Research and Therapy for Amyotrophic Lateral Sclerosis: Promises and Challenges

Juliana Ferreira Vasques, PHD, Leandro Coelho Teixeira Pinheiro, MSC, Renata Guedes de Jesus Gonçalves, PHD, Rosalia Mendez-Otero, MD, PHD, Fernanda Gubert, PHD

Pages 121-139

Gastrointestinal Status and Microbiota Shaping in Amyotrophic Lateral Sclerosis: A New Frontier for Targeting?

Letizia Mazzini, MD, Fabiola De Marchi, MD, Elena Niccolai, BSC, PHD, Jessica Mandrioli, MD, Amedeo Amedei, BSC

Pages 141-158


Pages 159-162