ISBN: 978-0-9944381-8-8


Janina E.E. Tirnitz-Parker, MSc, PhD (ed)
School of Pharmacy and Biomedical Sciences, Curtin Heath Innovation Research Institute, Curtin University, WA, Australia


Hepatocellular carcinoma (HCC), the most common form of liver cancer, has become a major global health problem and is responsible for a steadily increasing number of cancer-related deaths. Although the risk factors for HCC development are well known and great advances have been made through HBV vaccinations, direct-acting antivirals for HCV treatment, and aflatoxin eradication programs, the overall incidence and mortality rates of HCC are still rising. To tackle the burden of HCC, it is essential to understand the principle molecular and cellular processes as well as fundamental clinical challenges. This book provides an overview on several important disease aspects. Chapter 1 reviews recent studies assessing the potential cellular origins of HCC. Chapter 2 describes the newly discovered regulatory roles of the tumor microenvironment on tumor growth and progression. Chapters 3 and 4 outline the most commonly used in vitro systems and animal models of chronic liver disease and HCC in detail. Chapter 5 provides an overview of metabolic reprogramming and dysregulation of lipid metabolism as a newly recognized hallmark of HCC. Chapter 6 details the currently accepted standards and challenges for the surgical management of HCC, while Chapter 7 provides an overview of the recent developments in the field of tyrosine kinase inhibitors. Chapter 8 discusses multidrug resistance to chemotherapy and potential approaches to overcome this clinical obstacle. The book, written by experts from several countries, addresses each topic in sophisticated detail. It will be a valuable resource for clinicians and investigators who are interested in HCC.

Published: 2019-10-09


Darrell Crawford, Geoffrey McCaughan

Page vii


Janina E.E. Tirnitz-Parker

Page ix

The Role of the Tumor Microenvironment in the Development and Progression of Hepatocellular Carcinoma

Ina Sevic, Fiorella Mercedes Spinelli, María José Cantero, Andrea Reszegi, Ilona Kovalszky, Mariana Gabriela García, Laura Alaniz

Pages 29-45

In Vitro Models of the Liver: Disease Modeling, Drug Discovery and Clinical Applications

Scott D. Collins, Gloria Yuen, Thomas Tu, Magdalena A. Budzinska, Kevin Spring, Katherine Bryant, Nicholas A. Shackel

Pages 47-67

Mouse Models of Hepatocellular Carcinoma

Rodrigo Carlessi, Julia Köhn-Gaone, John K. Olynyk, Janina E. E. Tirnitz-Parker

Pages 69-94

The Role of Lipids in Hepatocellular Carcinoma

C. Nelson Hayes, Peiyi Zhang, Kazuaki Chayama

Pages 95-110

Current Topics and Perspectives in Surgical Management of Hepatocellular Carcinoma

Sebastian Lünse, Claus-Dieter Heidecke, Lars Ivo Partecke

Pages 111-125

Tyrosine Kinase Inhibitors in the Treatment of Hepatocellular Carcinoma

Tiffany Sandra Wai Ling Khoo, Arif Rehman, John K. Olynyk

Pages 127-139

Multidrug Resistance in Hepatocellular Carcinoma

Baojun Duan, Chen Huang, Jun Bai, Yu Lian Zhang, Xi Wang, Juan Yang, Jun Li

Pages 141-158


Pages 159-165