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Hepatocellular carcinoma (HCC) has become a major global health problem and is responsible for a steadily increasing number of cancer-related deaths. It is the most common form of liver cancer, with large disparities in incidence due to the geographical variation in the prevalence of risk factors. The high incidence rates of HCC in Africa and Asia are mainly attributed to the dietary exposure to aflatoxin B1 and chronic hepatitis B virus (HBV) infection. Western countries report fewer cases, with chronic hepatitis C virus (HCV) infection, alcohol abuse, metabolic syndrome, and non-alcoholic fatty liver disease as dominant causes. Although the risk factors for HCC development are well known and great advances have been made through HBV vaccinations, direct-acting antivirals for HCV treatment, and aflatoxin eradication programs, the overall incidence and mortality rates of HCC are still rising. To tackle the burden of HCC, it is essential to understand the principle molecular and cellular processes as well as fundamental clinical challenges. This book aims to provide an overview on several important disease aspects. CONTINUE READING.....
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