Cystic Fibrosis is a genetic condition that affects the lungs, digestive system, and other parts of the body by causing thick, sticky mucus to build up and block airways and ducts. This article begins by explaining the underlying cause of the condition, which involves mutations in the CFTR gene, and how these mutations lead to symptoms such as persistent lung infections, difficulty breathing, and digestive issues. It explores the diagnostic process, including newborn screening, sweat chloride tests, and genetic testing, and provides a detailed discussion of treatment options. These include medications like ivacaftor (Kalydeco) and therapies such as airway clearance techniques and pancreatic enzyme supplements. The article highlights advancements in CFTR modulators and their impact on managing cystic fibrosis. It also addresses the role of genetics, ongoing research, and how early intervention improves outcomes. The guide is organized to answer common questions, provide practical advice for living with cystic fibrosis, and support patients and caregivers with clear, actionable information. Written in simple terms, this resource ensures it is accessible and easy to understand for anyone seeking to learn about or manage cystic fibrosis effectively.