Breast cancer has become the most diagnosed cancer globally, surpassing lung and prostate cancers. In 2020, 2.3 million females were diagnosed with breast cancer worldwide. The incidence and related mortality from breast cancer continue to grow despite remarkable advances in our understanding of the biology of breast cancer and the availability of better therapeutic options. Therapies currently used to treat metastatic breast cancer extend the survival and quality of life of patients, but they are not curative. Therefore, a better understanding of the mechanisms involved in metastatic dissemination is of pivotal importance. This book provides a unique blend of carefully presented and structured information covering a broad array of relevant breast cancer-related issues. The first eight chapters cover breast cancer epidemiology, etiology, subtypes, current and emerging surgical innovations to treat and image breast cancer, a description of noninvasive lymphedema assessment methods to detect and track this important treatment complication, and the potential role of platelets and galectins in breast cancer metastasis. The last five chapters are devoted to the description of forward-looking albeit potential breast cancer treatment possibilities. In this regard, different chapters of the book describe novel research on the potential of ubiquitin-specific protease 18 (USP-18), ribosomal protein S6 kinase 1 (RPS6K1), the lysosomal system, nanoparticles, and proteolysis target chimeras as therapeutic agents for breast cancer. The range of clinical and translational research of breast cancer presented in this book will be of interest to healthcare professionals, clinicians, and basic scientists.

ISBN: 978-0-6453320-3-2; Exon Publications, Brisbane, Australia

Harvey N. Mayrovitz, PHD (Editor)
Department of Medical Education, Dr. Kiran C. Patel College of Allopathic Medicine, Nova Southeastern University, FL, USA


Published: 2022-08-06


R. Daniel Bonfil, PHD

Page vii


Harvey N. Mayrovitz, PHD

Pages ix-x


Pages xiii-xvi

The Epidemiology of Breast Cancer

Evelina Arzanova, MS, Harvey N. Mayrovitz, PHD

Pages 1-19

The Etiology of Breast Cancer

Claudia Admoun, BS, Harvey N. Mayrovitz, PHD

Pages 21-30

Subtypes of Breast Cancer

Erasmo Orrantia-Borunda, PHD, Patricia Anchondo-Nuñez, Dr., Lucero Evelia Acuña-Aguilar, MSC, Francisco Octavio Gómez-Valles, MD, Claudia Adriana Ramírez Valdespino, PHD

Pages 31-42

Current Surgical Innovations in the Treatment of Breast Cancer

Jessica Crystal, MD, Juan Mella-Catinchi, MD, Kyle Xu, MD, Daniel Weingrad, MD

Pages 43-62

Platelets in Hematogenous Breast Cancer Metastasis: Partners in Crime

Savannah R. Free, BS, Kermit L. Carraway III, PHD

Pages 101-114

Role of Galectins in Metastatic Breast Cancer

Jessie J. Grazier, BS, Paul W. Sylvester, PHD

Pages 115-130

Ubiquitin-Specific Peptidase 18: a Multifaceted Protein Participating in Breast Cancer

Angeles C. Tecalco-Cruz, PHD, Josué O. Ramírez-Jarquín, PHD, Jesús Zepeda-Cervantes, PHD, Helena Solleiro-Villavicencio, PHD, María Jazmín Abraham-Juárez, PHD

Pages 131-148

Nanomaterials for Breast Cancer

Erasmo Orrantia-Borunda, PHD, Lucero Evelia Acuña Aguilar, MSC, Claudia Adriana Ramírez Valdespino, PHD

Pages 149-162

Targeting RPS6K1 for Refractory Breast Cancer Therapy

Jayalakshmi Sridhar, PHD, Rajesh Komati, PHD, Satyendra Kumar, MD, PHD

Pages 163-178

Novel Breast Cancer Treatment by Targeting Estrogen Receptor-Alpha Stability Using Proteolysis-Targeting Chimeras (PROTACs) Technology

Angeles C. Tecalco-Cruz, PHD, Josué Orlando Ramírez-Jarquín, PHD, Marina Macías-Silva, PHD, Marcela Sosa-Garrocho, PHD, César López-Camarillo, PHD

Pages 179-193

Engaging the Lysosome and Lysosome-Dependent Cell Death in Cancer

Anastasia L. Berg, PHD, Ashley Rowson-Hodel, PHD, Madelyn R. Wheeler, MD, Michelle Hu, BS, Savannah Free, BS, Kermit L. Carraway III, PHD

Pages 195-230


Pages 231-234