Advancements in Cancer Research focuses on selected topics in Oral and Maxillofacial Oncology, Radiation Oncology, Pediatric Oncology, and Hematological Oncology. The book explores the advancements in our understanding of severe radiotherapy side effects such as osteoradionecrosis of the jaws and radiation-induced trismus, addressing their clinical and radiological features, and strategies for diagnosis and management. It underscores the quality-of-life concerns arising from radiotherapy, collecting data on the physical, social, and emotional effects of these conditions. Advancements in Cancer Research also discusses innovative treatments for brain metastases and chronic lymphocytic leukemia. It addresses the challenges and advancements in treating neuroblastoma, a prevalent infant tumor. The book offers insights into dental implant-supported prostheses, an emerging oral rehabilitation option for patients who have undergone radiotherapy. One chapter is dedicated to cell microarrays, a powerful technique for studying numerous tissue samples on a single slide, highlighting its potential for drug screening and biomarker tracking. The book stands as a testament to the collaborative effort of many authors, who have contributed their expertise in various areas of oncology, fostering a better understanding of cancer research advancements. It is primarily designed for clinicians, although basic scientists will find valuable insights.

Advancements in Cancer Research
ISBN: 978-0-6453320-9-4

Consolato M. Sergi, MD, PhD, MPH, FRCPC, FCAP (Editor)
Anatomic Pathology Division, Children’s Hospital of Eastern Ontario, ON, Canada

DOI: https://doi.org/10.36255/advancements-in-cancer-research

Published: 2023-08-17

Foreword

Josef Hager, MD, PhD, Mag.

Page vii

Preface

Consolato M. Sergi, MD, PhD, FRCPC, FCAP

Pages ix-x

Challenges in the Radiological Diagnosis of Osteoradionecrosis of the Jaw in Head and Neck Cancer Patients

Busra Yilmaz, DDS, MSC, Efsun Somay, DDS, PHD, Ahmet Kucuk, MD, Berrin Pehlivan, MD, Ugur Selek, MD, Erkan Topkan, MD

Pages 1-22

Definitions of Radiation-induced Trismus in Head and Neck Cancer: Current Concepts and Controversies

Efsun Somay, DDS, PHD, Ahmet Kucuk, MD, Busra Yilmaz, DDS, MSC, Berrin Pehlivan, MD, Ugur Selek, MD, Erkan Topkan, MD

Pages 23-40

Assessment of the Impact of Osteoradionecrosis on Quality-of-Life Measures in Patients with Head and Neck Cancer

Efsun Somay, DDS, PHD, Busra Yilmaz, DDS, MSC, Erkan Topkan, MD, Ahmet Kucuk, MD, Berrin Pehlivan, MD, Ugur Selek, MD

Pages 41-56

Combined Stereotactic Radiosurgery and Immune Checkpoint Inhibitors for the Treatment of Brain Metastasis

Ahmet Kucuk, MD, Erkan Topkan, MD, Nulifer Kılıc Durankus, MD, Sukran Senyurek, MD, Eyub Yasar Akdemir, MD, Duygu Sezen, MD, Yasemin Bolukbasi, MD, Ugur Selek, MD, Berrin Pehlivan, MD

Pages 57-74

Preoperative Radiosurgical Management of Brain Metastases: Evidence and Challenges

Erkan Topkan, MD, Ahmet Kucuk, MD, Sukran Senyurek, MD, Duygu Sezen, MD, Nulifer Kılıc Durankus, MD, Eyub Yasar Akdemir, MD, Yasemin Bolukbasi, MD, Berrin Pehlivan, MD, Ugur Selek, MD

Pages 75-91

Radiotherapy and Dental Implant Applications in Patients with Head and Neck Cancer

Efsun Somay, MD, Busra Yılmaz, MD, Erkan Topkan, MD, Berrin Pehlivan, MD, Ugur Selek, MD

Pages 117-131

Index

Pages 145-147