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Consolato M. Sergi, MD, PhD, FRCPC, FCAP

The book Advancements in Cancer Research focuses on selected areas of Oral and Maxillofacial Oncology, Radiation Oncology, Pediatric Oncology, and Hematological Oncology. The contents are primarily designed for clinicians, although basic scientists will also find considerable value. Chapter 1 explores osteoradionecrosis of the jaws, a severe side effect observed in 2-22% of patients undergoing radiation therapy or concurrent chemo-radiotherapy for head and neck cancers. There is currently no consensus on the precise diagnosis of this condition. The chapter enhances our understanding of its clinical and radiological features, presenting strategies for accurate diagnosis, with particular emphasis on radiological and nuclear medicine techniques. Chapter 2 focuses on radiation-induced trismus, a debilitating consequence of radiotherapy in patients with head and neck cancers, which interferes with daily activities such as eating, speaking, chewing, and maintaining oral hygiene. This chapter elucidates current concepts, debates surrounding the definitions, and challenges encountered in managing this condition due to variations in these definitions. Chapter 3 addresses quality of life as a significant concern arising from radiotherapy, which often leads to facial deformity, pain, fractures, devitalized bone, fistulas, dysesthesia or anesthesia, trismus, and difficulties in chewing and swallowing, along with localized or systemic infections. This chapter compiles data on the physical, social, and emotional effects of osteoradionecrosis of the jaws as determined by general or specific quality of life surveys of head and neck cancer. CONTINUE READING…..


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