Combined Stereotactic Radiosurgery and Immune Checkpoint Inhibitors for the Treatment of Brain Metastasis | Exon Publications

Advancements in Cancer Research Book Cover

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Published: Jan 3, 2023

DOI: https://doi.org/10.36255/treatment-brain-metastasis

Keywords:

combination therapy for brain metastasis, immune checkpoint inhibitors for brain metastasis, immunotherapy for brain metastasis, stereotactic radiosurgery for brain metastasis, stereotactic radiosurgery

Ahmet Kucuk, MD

Mersin City Education and Research Hospital, Radiation Oncology Clinics, Mersin, Turkey

Erkan Topkan, MD

Baskent University Medical Faculty, Department of Radiation Oncology, Adana, Turkey

Nulifer Kılıc Durankus, MD

Koc University, School of Medicine, Department of Radiation Oncology, Istanbul, Turkey

Sukran Senyurek, MD

Koc University, School of Medicine, Department of Radiation Oncology, Istanbul, Turkey

Eyub Yasar Akdemir, MD

Koc University, School of Medicine, Department of Radiation Oncology, Istanbul, Turkey

Duygu Sezen, MD

Koc University, School of Medicine, Department of Radiation Oncology, Istanbul, Turkey

Yasemin Bolukbasi, MD

Koc University, School of Medicine, Department of Radiation Oncology, Istanbul, Turkey

Ugur Selek, MD

Koc University, School of Medicine, Department of Radiation Oncology, Istanbul, Turkey

Berrin Pehlivan, MD

Department of Radiation Oncology, Bahcesehir University, Istanbul, Turkey

ABSTRACT

Metastasis of solid tumors to the brain occurs in about 30% of cases. Surgery and whole-brain radiotherapy have been the standard treatments with very limited success rates. As a result of the unsatisfactory local control and long-term survival outcomes, stereotactic radiosurgery has been used as an alternative to surgery and whole-brain radiotherapy, or to improve the outcomes in conjunction with other treatments. However, stereotactic radiosurgery does not produce the desired survival results despite the striking increases in local control rates, primarily because of deaths attributed to extracranial systemic disease progression or unavoidably fatal distant brain recurrences. Lately, immunotherapy has become a part, or mainstay, of treatment algorithms for many cancer types. Several authors have proposed the integration of stereotactic radiosurgery and immunotherapy for the treatment of brain metastasis. This chapter evaluates the efficacy and safety of combining novel immunotherapeutics with traditional stereotactic radiosurgery for the treatment of brain metastasis.

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Book

Advancements in Cancer Research

Section

Chapter 4

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