ISBN: 978-0-9944381-9-5


Holger Husi, Dr sc nat (ed)
Institute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, Inverness, UK; Division of Biomedical Sciences Centre for Health Science, University of Highlands and Islands, UK


Our understanding of biology has undergone a revolution in the past 20 years, driven by our ability to capture, store, interrogate and analyze the ever-increasing volumes of ‘omics’ data. Computational Biology, an integrated approach employing high performance computers, state-of-the art software and algorithms, mathematical modeling and statistical analyses have enabled us to unravel the seemingly impenetrable complexity of biological systems. This book draws together many of the latest cutting-edge developments in the field of Computational Biology. Each chapter draws on the expertise of leading researchers in the field to highlight the utility of specific technologies. The breadth of the text is impressive - from integrative biology in human diseases through the various branches of epigenomics, metabolomics and proteomics to biological sequencing and deep learning. Computational biology approaches for image-based analysis of multicellular spheroids, feature selection using entropy and cellular cryo-electron tomography structural pattern mining are covered. In addition, the key role of statistics in the analysis of high-dimensional multiset omics data and RNA sequencing are discussed in dedicated chapters. This book would have broad appeal to anyone with an interest in cutting edge computational biology.

Published: 2019-10-31


Ian Megson

Page vii


Holger Husi

Pages ix-xi


Pages xiii-xvii

Integrative Biology Approaches Applied to Human Diseases

Alysson H. Urbanski, José D. Araujo, Rachel Creighton, Helder I. Nakaya

Pages 19-36

Deep Learning in Omics Data Analysis and Precision Medicine

Jordi Martorell-Marugán, Siham Tabik, Yassir Benhammou, Coral del Val, Igor Zwir, Francisco Herrera, Pedro Carmona-Sáez

Pages 37-53

Biological Sequence Analysis

Usman Saeed, Zainab Usman

Pages 55-69

Computational Epigenomics: From Fundamental Research to Disease Prediction and Risk Assessment

Mohamed-Amin Choukrallah, Florian Martin, Nicolas Sierro, Julia Hoeng, Nikolai V. Ivanov, Manuel C. Peitsch

Pages 101-118

Computational Approaches in Proteomics

Karla Cervantes Gracia, Holger Husi

Pages 119-142

Cheminformatics and Computational Approaches in Metabolomics

Marco Fernandes, Bela Sanches, Holger Husi

Pages 143-159

Feature Selection in Microarray Data Using Entropy Information

Ali Reza Soltanian, Niloofar Rabiei, Fatemeh Bahreini

Pages 161-174


Pages 187-194