Zika Virus Disease is a mosquito-borne illness that can cause mild symptoms such as fever, rash, and joint pain but is particularly concerning for its potential to cause severe birth defects and neurological complications. This article provides a detailed understanding of Zika Virus Disease, serving as a valuable resource for the public. The article begins with an introduction to the virus, explaining its origins and primary modes of transmission. It covers the causes of infection, including how the virus is transmitted by mosquitoes and other methods. The article discusses the different strains of the virus, risk factors, and how common the disease is. Readers will learn about the signs and symptoms, how the disease spreads, and the methods used for diagnosis. The pathophysiology of the virus is explained, along with the treatment options available, which mainly focus on supportive care. Preventive measures are outlined to help reduce the risk of infection. The article concludes with a summary emphasizing the importance of early detection, appropriate treatment, and preventive measures. All information is presented in simple terms to ensure it is understandable for all readers. This is part of the “Public Education Series” initiative of Exon Publications.