Neurofibromatosis is a group of genetic disorders that cause tumors to form on nerves throughout the body, leading to a range of physical, neurological, and cosmetic challenges. This article provides a comprehensive guide to understanding Neurofibromatosis, its causes, and how it is managed. It begins by explaining the condition and its three main types: Neurofibromatosis type 1 (NF1), Neurofibromatosis type 2 (NF2), and Schwannomatosis, each with unique symptoms and complications. The article explores the genetic basis of the disorder, detailing the role of mutations in the NF1, NF2, SMARCB1, and LZTR1 genes. The article outlines the symptoms associated with each type, such as café-au-lait spots, hearing loss, chronic pain, and neurological issues. It describes the diagnostic process, including clinical evaluations, imaging studies, and genetic testing. Treatment options are explained in detail, highlighting surgical interventions, medications like selumetinib (Koselugo), and supportive therapies. The article also offers advice on living with Neurofibromatosis, emphasizing the importance of regular medical care and emotional support. Organized to provide clear and comprehensive information, this book ensures that all readers, including patients and their families, can easily understand and apply the knowledge to manage Neurofibromatosis effectively. This article is part of the 'Public Education Series' initiative by Exon Publications.