ISBN: 978-0-9944381-2-6


Steven De Vleeschouwer, MD, PhD (ed)
Department of Neurosurgery, University Hospitals Leuven, Belgium


Glioblastoma is the commonest and the most lethal brain tumor. In this book, 71 experts from around the globe come together to give a timely, unique and exhaustive compilation of preclinical and clinical knowledge and concepts of glioblastoma under three sections: understanding glioblastoma in the lab; managing glioblastoma in the clinic; and upcoming cutting-edge innovations. In section one, seven chapters provide a comprehensive overview of the molecular genetics, biological hallmarks and current state-of-the-art preclinical animal models in glioblastoma research. In section two, eight chapters deal with the many diagnostic, therapeutic and prognostic management challenges physicians are facing every day. In section three, six chapters try to capture innovative approaches and techniques that might have the potential to gain impact in the field in the coming years.

Published: 2017-09-20


Prof. Dr. med. W. Stummer

Page ix


Steven De Vleeschouwer

Pages xi-xii



Molecular Genetics of Secondary Glioblastoma

Alireza Mansouri, Jason Karamchandani, Sunit Das

Pages 27-42

Cancer Stem-Like Cells in Glioblastoma

Mathilde Cheray, Gaëlle Bégaud, Elise Deluche, Alexandre Nivet, Serge Battu, Fabrice Lalloué, Mireille Verdier, Barbara Bessette

Pages 59-71

Molecular Mechanisms of Glioma Cell Motility

Angela Armento, Jakob Ehlers, Sonja Schötterl, Ulrike Naumann

Pages 73-93

Noncoding RNAs in Glioblastoma

Ying Zhang, Nichola Cruickshanks, Mary Pahuski, Fang Yuan, Anindya Dutta, David Schiff, Benjamin Purow, Roger Abounader

Pages 95-130

Mouse Models of Glioblastoma

Noriyuki Kijima, Yonehiro Kanemura

Pages 131-139

Epidemiology and Outcome of Glioblastoma

Ahmad Faleh Tamimi, Malik Juweid

Pages 143-153

PET for Therapy Response Assessment in Glioblastoma

Julie Bolcaen, Marjan Acou, Benedicte Descamps, Ken Kersemans, Karel Deblaere, Christian Vanhove, Ingeborg Goethals

Pages 175-195

Current Standards of Care in Glioblastoma Therapy

Catarina Fernandes, Andreia Costa, Lígia Osório, Rita Costa Lago, Paulo Linhares, Bruno Carvalho, Cláudia Caeiro

Pages 197-241

Surgical Management of Glioblastoma

Salvador Manrique-Guzmán, Tenoch Herrada-Pineda, Francisco Revilla-Pacheco

Pages 243-261

Recurring Glioblastoma: A Case for Reoperation?

Joost Dejaegher, Steven De Vleeschouwer

Pages 281-296

Pediatric Glioblastoma

Kuntal Kanti Das, Raj Kumar

Pages 297-312


Pages 427-432