WILMS TUMOR
ISBN: 978-0-9944381-1-9

 

Marry M. van den Heuvel-Eibrink, MD, PhD (ed)
Princess Maxima Center for Pediatric Oncology/Hematology, Lundlaan 6, 3584 EA Utrecht, The Netherlands

 

Wilms tumor is a rare kidney cancer that is usually diagnosed in children under the age of six. Wilms tumor is mostly the result of aberrations in WT1 gene, located on chromosome 11p13. In addition to being a risk factor for Wilms tumor, WT1 aberrations cause extra renal complications and other malignancies. This book brings together the basic and clinical aspects of Wilms tumor and WT1 research under three sections. Section I provides a comprehensive guide to the epidemiology, diagnostics, management, and treatment of Wilms tumor. Section II covers the biological aspects of Wilms tumor and WT1. Section III focuses on the role of WT1 in cardiac development, prostate cancer, glioblastoma and minimal residual disease.

Published: 2016-03-23

Foreword

Bengt Sandstedt

Pages ix-xi

Preface

Marry M. van den Heuvel-Eibrink

Pages xiii-xv

Contributors

Pages xvii-xxiii

Wilms’ Tumour – Histology and Differential Diagnosis

Sergey D. Popov, Neil J. Sebire, Gordan M. Vujanic

Pages 3-21

The Clinical Relevance of Age at Presentation in Nephroblastoma

Saskia L. Gooskens, Heidi Segers, Kathy Pritchard-Jones, Norbert Graf, Jeffrey S. Dome, Marry M. van den Heuvel-Eibrink

Pages 23-30

Management of Bilateral Wilms Tumours

Alastair J. W. Millar, Sharon Cox, Alan Davidson

Pages 61-76

Extrarenal Wilms’ Tumor: Challenges in Diagnosis, Embryology, Treatment and Prognosis

Reza Shojaeian, Mehran Hiradfar, Parisa Saeedi Sharifabad, Nona Zabolinejad

Pages 77-93

Neoadjuvant Transcatheter Arterial Chemoembolization and Systemic Chemotherapy for the Treatment of Wilms Tumor

Min-Ju Li, Da-Xing Tang, Yong Huang, De-Hua Wu, Jin-Hu Wang, Can Lai, Hong-Feng Tang, Qiang Shu

Pages 95-112

Dendritic Cell-Based Cancer Immunotherapy Targeting Wilms’ Tumor 1 for Pediatric Cancer

Shigetaka Shimodaira, Koichi Hirabayashi, Ryu Yanagisawa, Yumiko Higuchi, Kenji Sano, Tomonobu Koizumi

Pages 113-130

Chronic Kidney Disease in Wilms Tumour Survivors – What Do We Know Today?

Joanna Stefanowicz, Mateusz Kosiak, Wojciech Kosiak, Beata S. Lipska-Ziętkiewicz

Pages 131-145

Gene Expression in Wilms Tumor: Disturbance of the Wnt Signaling Pathway and MicroRNA Biogenesis

Dirce Maria Carraro, Rodrigo F. Ramalho, Mariana Maschietto

Pages 149-162

WT1 in Cardiac Development and Disease

Sjoerd N. Duim, Marie-José Goumans, Boudewijn P. T. Kruithof

Pages 211-233

Functional Role of WT1 in Prostate Cancer

Gail C. Fraizer, Kurtis Eisermann, Sony Pandey, Adina Brett-Morris, Anton Bazarov, Sarah Nock, Nirmala Ghimirey, Steven J. Kuerbitz

Pages 235-259

Functional Roles of Wilms’ Tumor 1 (WT1) in Malignant Brain Tumors

Noriyuki Kijima, Naoya Hashimoto, Yasuyoshi Chiba, Yasunori Fujimoto, Haruo Sugiyama, Toshiki Yoshimine

Pages 261-272

Wilms’ Tumor Gene (WT1) Expression and Minimal Residual Disease in Acute Myeloid Leukemia

Giovanni Rossi, Maria Marta Minervini, Angelo Michele Carella, Lorella Melillo, Nicola Cascavilla

Pages 273-285

Index

Pages 287-293