ISBN: 978-0-9944381-0-2


Xiaogang Li, PhD (ed)
Department of Internal Medicine, Department of Biochemistry and Molecular Biology, University of Kansas Medical Center, Kansas City, KS 66160, USA


Polycystic kidney disease (PKD) is characterized by the presence of fluid-filled cysts in the kidneys. It is the fourth most common cause of chronic renal insufficiency or end-stage kidney disease. This book focuses on the basic and clinical aspects of the burgeoning PKD research under three sections. Section 1 provides a comprehensive guide to the diagnosis, management and treatment of PKD. Section 2 covers most of the fundamental molecular and cellular mechanisms underlying PKD, and how this knowledge is contributing to the development of potential novel therapeutic agents. Finally, section 3 focuses on extra-renal or secondary complications of PKD.

Published: 2015-11-18


Jared J. Grantham

Pages ix-x


Xiaogang Li

Pages xi-xiii

Differential Diagnosis of Autosomal Dominant Polycystic Kidney Disease

Mariana Alves, Teresa Fonseca, Edgar A. F. de Almeida

Pages 3-19

Childhood Polycystic Kidney Disease

Ameya Patil, William E. Sweeney Jr., Ellis D. Avner, Cynthia Pan

Pages 21-60

Diagnosis and Treatment Modalities of Symptomatic Polycystic Kidney Disease

Sanem Guler, Sertac Cimen, Scott Hurton, Michele Molinari

Pages 75-94

Blood Pressure Control for Polycystic Kidney Disease

Rudolf P. Wüthrich, Andreas D. Kistler, Daniel Rodriguez, Sarika Kapoor, Changlin Mei

Pages 95-108

Clinical Trials in Autosomal Dominant Polycystic Kidney Disease

Alan S.L. Yu, Mireille El-Ters, Franz T. Winklhofer

Pages 109-135

Polycystins and Molecular Basis of Autosomal Dominant Polycystic Kidney Disease

Frederico Moraes Ferreira, Elieser Hitoshi Watanabe, Luiz Fernando Onuchic

Pages 139-167

MicroRNAs and Polycystic Kidney Disease

Sachin Hajarnis, Ronak Lakhia, Vishal Patel

Pages 313-334

Autosomal Dominant Polycystic Kidney Disease Induced by Ciliary Defects

Jong Hoon Park, Yu Mi Woo,, Je Yeong Ko, Do Yeon Kim

Pages 375-396

The Liver and Polycystic Kidney Disease

Mônica Souza de Miranda Henriques, Erick José de Morais Villar

Pages 425-441

Seminal Vesicles in Autosomal Dominant Polycystic Kidney Disease

Jin Ah Kim, Jon D. Blumenfeld, Martin R. Prince

Pages 443-455

Rapidly Progressive Glomerulonephritis in Autosomal Dominant Polycystic Kidney Disease

Adey A.A. Hasan, Raafat Makary, Leighton R. James

Pages 471-483


Pages 485-488