WeMine Aligned Pattern Clustering System for Biosequence Pattern Analysis
Article Sidebar
Main Article Content
ABSTRACT
A major challenge in bioinformatics is discovering functional regions in biosequences. These regions may correspond to folded structures, physicochemical functionality, or mutation hotspots. The identification of functional regions in biosequences is essential to better understand biological mechanisms, design new drugs, and uncover novel knowledge concerning sporadic and genetic diseases. Pattern analysis and WeMine aligned pattern clustering (APC) systems enable the discovery of conserved regions with adaptive width and mutations, including frameshift, without relying on prior knowledge or exhaustive search. They align and rank patterns in local and distant correlated regions with statistical support within, and between, sequences. This chapter provides an overview of the WeMine APC and its utility in identifying functional regions such as protein binding sites, predicting pairwise interactions between protein-DNA and protein-protein network, and finding correlations among patterns and residues with class labels. Pattern analysis and WeMine APC could play an important role in personalized medicine, gene therapy, biomarker identification and drug discovery.
Downloads
Metrics
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Copyright of individual chapters belongs to the respective authors. The authors grant unrestricted publishing and distribution rights to the publisher. The electronic versions of the chapters are published under Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). Users are allowed to share and adapt the chapters for any non-commercial purposes as long as the authors and the publisher are explicitly identified and properly acknowledged as the original source. The books in their entirety are subject to copyright by the publisher. The reproduction, modification, republication and display of the books in their entirety, in any form, by anyone, for commercial purposes are strictly prohibited without the written consent of the publisher.