The Role of MicroRNA in the Metastatic Phenotype of Bladder Cancer

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Aaron Perecman, MD
Adam Wiggins, MD
Jonathan Xu, MD
Sanjna Das, BS
Thomas Kalantzakos, BA
Travis Sullivan, MS
Kimberly Rieger-Christ, PHD


Bladder cancer is among the most common cancers globally, with significant mortality associated with more advanced disease. Early detection and diagnostic accuracy are thus fundamental to the clinical pathway for managing bladder cancer. MicroRNA (miRNA) are small, non-coding segments of RNA that regulate gene expression and have been implicated in the process of carcinogenesis. Dysregulation and aberrant expression of miRNAs have been shown to have both oncogenic and tumor suppressive effects. A vast number of miRNA, across the entire field of cancer biology, have already been identified and characterized, and many of these have been associated with bladder cancer. These miRNAs have furthered our understanding of the genetic profile of bladder cancer, and ultimately, may be utilized in the detection, prognosis, and treatment of this disease. This chapter focuses on the role of miRNA in the pathogenesis of metastatic bladder cancer and overviews many of the miRNA thought to be associated with bladder cancer.  Additionally, this chapter explores the clinical utilities of miRNAs in bladder cancer to serve as biomarkers and guide individualized treatment.


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