Canonical Transient Receptor Potential Channels as Novel Targets for Antiepileptic Drugs
Main Article Content
ABSTRACT
Canonical transient receptor potential channels (TRPC) are a family of calcium-permeable cation channels that have emerged as novel molecular targets for epilepsy and other human diseases in recent years. Cryogenic electron microscopic structures for the majority of TRPC have been resolved and these structures have provided new insights regarding the gating mechanisms of TRPC and aided the developments of small molecule modulators of these channels. Small molecule modulators target several TRPC and show promise as anti-seizure drugs. However, the pharmacokinetics need improvement, and better understanding of native TRPC will facilitate future drug development.
Downloads
Metrics
Article Details
This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.
Copyright of individual chapters belongs to the respective authors. The authors grant unrestricted publishing and distribution rights to the publisher. The electronic versions of the chapters are published under Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0). Users are allowed to share and adapt the chapters for any non-commercial purposes as long as the authors and the publisher are explicitly identified and properly acknowledged as the original source. The books in their entirety are subject to copyright by the publisher. The reproduction, modification, republication and display of the books in their entirety, in any form, by anyone, for commercial purposes are strictly prohibited without the written consent of the publisher.