Mesothelioma is a rare and aggressive cancer primarily caused by asbestos exposure, affecting the protective lining of internal organs. This article serves as a comprehensive guide to understanding mesothelioma, offering essential information for patients, caregivers, and the general public. It begins with an introduction to the disease and its significance, followed by a clear explanation of what mesothelioma is, its types, and how it affects the body. The guide discusses the epidemiology of the disease, highlighting its global impact and the populations most at risk. It provides detailed insights into the causes, symptoms, and complications of mesothelioma, making it easier for readers to recognize the condition early. The book explores the diagnostic process, emphasizing the importance of accurate and timely detection. Treatment options, including surgery, chemotherapy, and emerging therapies like immunotherapy, are discussed in detail. Additional contents focus on the prognosis, prevention strategies, and practical advice for living with the disease. The guide concludes with actionable information to support patients and their loved ones. Organized into straightforward sections and written in clear language, this guide ensures that complex medical concepts are simplified, making the information accessible and easy to understand for all readers. This is part of the 'Public Education Series' initiative by Exon Publications.