Radiomics in Malignant Lymphomas
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ABSTRACT
Imaging has a pivotal role in the management of lymphoma patients, from the diagnosis to the therapy assessment. Its importance has grown exponentially in the last years thanks to the introduction of 18F-fluoro deoxy-glucose positron emission tomography/computed tomography (18FDG-PET/CT) that permitted to design clinical trial in which treatment was adapted on the basis of metabolic response obtained in the early phase of treatment, usually after two cycles of chemotherapy. This approach has been successfully translated in clinical practice thanks to the introduction of the Deauville criteria, which is currently the standard method for PET/CT imaging reporting and metabolic response assessment. The introduction of quantitative evaluation of baseline PET/CT images provided new functional indices such as metabolic tumor volume (MTV) that demonstrated good value in predicting patient outcome. Recently, radiomic analysis has allowed the extraction of a wide variety of quantitative data that reflect biological characteristics of disease providing additional promising prognostic biomarkers in lymphomas.
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