MetastamiRs in Renal Cell Carcinoma: An Overview of MicroRNA Implicated in Metastatic Kidney Cancer
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ABSTRACT
MicroRNAs are short noncoding RNAs that regulate post-transcriptional protein expression. Aberrant microRNA expression has been widely implicated in cancer biology with various effects depending on the affected downstream target(s). In renal cell carcinoma, microRNAs have been shown to influence metastasis by targeting oncogenes or tumor suppressors in complex regulatory networks - leading them to be coined “metastamiRs.” This chapter aims to identify the microRNAs responsible for metastasis in renal cell carcinoma, review their molecular function and oncologic outcome, and discuss their potential roles for diagnosis, prognosis, and therapy.
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