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Hepatoblastoma is the most common liver cancer in children aged 3 years and younger. The differential diagnosis of this neoplasm is crucial for the proper management. Recent additions to protocols of the International Society of Pediatric Oncology and Children’s Oncology Group have been key in tackling this oncological disease. This chapter provides an overview of the etiology, pathogenesis, epidemiology, incidence, symptoms, and therapeutic considerations of hepatoblastoma. The diagnostic measures necessary from a surgical point of view and the essential operational and technical considerations for the various stages of hepatoblastoma are discussed.
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