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More information about this initiative can be found by visiting the link: <a href="https://exonpublications.com/index.php/exon/public-education-series">Public Education Series</a>. The purpose of this book is to provide essential, easily understandable information about polycystic kidney disease (PKD) to the general public. To achieve this, the book avoids scientific jargon and complex medical terminology. It primarily draws from our earlier medical text, <a href="https://exonpublications.com/index.php/exon/issue/view/4">Polycystic Kidney Disease</a>, and is supplemented by selected articles from PubMed. <a href="https://exonpublications.com/index.php/exon/article/view/preface-polycystic-kidney-disease/1392">CONTINUE READING.....</a></p> 2024-05-28T17:26:54+10:00 Copyright (c) 2024 Exon Publications https://exonpublications.com/index.php/exon/article/view/polycystic-kidney-disease-overview Polycystic Kidney Disease: An Overview 2024-05-28T17:28:59+10:00 Polycystic Kidney Disease: An Overview books@exonpublications.com <p><strong>ABSTRACT<br></strong>Polycystic Kidney Disease (PKD) is a common genetic disorder where multiple fluid-filled cysts develop in the kidneys, causing them to enlarge and lose function over time. This chapter provides an overview of PKD, starting with its definition and the types—Autosomal Dominant PKD (ADPKD) and Autosomal Recessive PKD (ARPKD). It explores the history and discovery of PKD, tracing its understanding from ancient observations to modern genetic research. The prevalence and demographics of PKD are examined, highlighting its widespread impact across different populations and age groups.<strong><br></strong></p> <p><em><strong>Cite as:</strong></em> Polycystic Kidney Disease: An Overview. In: Polycystic Kidney Disease: Public Education. Brisbane (AU): Exon Publications; 2024. Online first 2024 May 28. ISBN: 978-0-6458663-8-4<br>DOI: https://doi.org/10.36255/polycystic-kidney-disease-overview</p> 2024-05-28T00:00:00+10:00 Copyright (c) 2024 Exon Publications https://exonpublications.com/index.php/exon/article/view/polycystic-kidney-disease-genetics-cyst-formation-inheritance Genetics, Cyst Formation, and Inheritance Patterns of Polycystic Kidney Disease 2024-05-28T17:28:59+10:00 Genetics, Cyst Formation, and Inheritance Patterns of Polycystic Kidney Disease books@exonpublications.com <p><strong>ABSTRACT<br></strong>Polycystic Kidney Disease (PKD) is a genetic disorder characterized by the formation of numerous cysts in the kidneys. This chapter explores the genetic mutations, cyst formation, molecular mechanisms of cyst formation, inheritance patterns, and the role of genetic testing and counseling for PKD. ADPKD (Autosomal Dominant Polycystic Kidney Disease) and ARPKD (Autosomal Recessive Polycystic Kidney Disease) are the two main types of PKD, each caused by mutations in different genes and inherited in different ways. Understanding the molecular pathways affected by these mutations, such as cAMP signaling and mTOR pathways, helps in comprehending how the disease progresses. Genetic testing can confirm a diagnosis of PKD, while genetic counseling provides crucial support and information for individuals and families.</p> <p><strong><em>Cite as:</em></strong> Genetics, Cyst Formation, and Inheritance Patterns of Polycystic Kidney Disease. In: Polycystic Kidney Disease: Public Education. Brisbane (AU): Exon Publications; 2024. Online first 2024 May 28. ISBN: 978-0-6458663-8-4<br>DOI: https://doi.org/10.36255/polycystic-kidney-disease-genetics-cyst-formation-inheritance</p> 2024-05-28T05:56:24+10:00 Copyright (c) 2024 Exon Publications https://exonpublications.com/index.php/exon/article/view/symptoms-diagnosis-polycystic-kidney-disease Symptoms and Diagnosis of Polycystic Kidney Disease 2024-05-28T17:28:59+10:00 Symptoms and Diagnosis of Polycystic Kidney Disease books@exonpublications.com <p><strong>ABSTRACT</strong><br>Polycystic kidney disease (PKD) is a genetic condition that leads to the development of numerous cysts in the kidneys, causing various symptoms and complications. This chapter examines the common symptoms of PKD and the diagnostic methods used to identify the disease. First, it provides an overview of how symptoms like pain, high blood pressure, and kidney function decline manifest and progress, and then discusses diagnostic tools like imaging and genetic tests.</p> <p><strong><em>Cite as:</em></strong> Symptoms and Diagnosis of Polycystic Kidney Disease. In: Polycystic Kidney Disease: Public Education. Brisbane (AU): Exon Publications; 2024. Online first 2024 May 28. ISBN: 978-0-6458663-8-4<br>DOI: https://doi.org/10.36255/symptoms-diagnosis-polycystic-kidney-disease</p> 2024-05-28T00:00:00+10:00 Copyright (c) 2024 Exon Publications https://exonpublications.com/index.php/exon/article/view/kidney-function-other-manifestations-polycystic-kidney-disease Kidney Function and Other Manifestations of Polycystic Kidney Disease 2024-05-28T17:28:59+10:00 Kidney Function and Other Manifestations of Polycystic Kidney Disease books@exonpublications.com <p><strong>ABSTRACT</strong><br>Polycystic Kidney Disease (PKD) is a genetic disorder that leads to the formation of numerous fluid-filled cysts in the kidneys and affects other parts of the body. Genetic mutations disrupt normal cellular functions, leading to uncontrolled cell growth and cyst formation. As these cysts expand, they impair the kidneys' ability to filter waste, resulting in chronic kidney disease and potentially end-stage renal disease. PKD also causes issues beyond the kidneys, such as liver cysts, aneurysms, heart problems, and digestive issues. This chapter explores the impact of PKD on kidney function, and the extrarenal manifestations of the disease.</p> <p><em><strong>Cite as:</strong></em> Kidney Function and Other Manifestations of Polycystic Kidney Disease. In: Polycystic Kidney Disease: Public Education. Brisbane (AU): Exon Publications, 2024. Online first 2024 May 28. ISBN: 978-0-6458663-8-4<br>DOI: https://doi.org/10.36255/kidney-function-other-manifestations-polycystic-kidney-disease </p> 2024-05-28T10:01:18+10:00 Copyright (c) 2024 Exon Publications https://exonpublications.com/index.php/exon/article/view/treatment-management-polycystic-kidney-disease Treatment and Management of Polycystic Kidney Disease 2024-05-28T17:28:59+10:00 Treatment and Management of Polycystic Kidney Disease books@exonpublications.com <p><strong>ABSTRACT</strong><br>Polycystic Kidney Disease (PKD) is a genetic disorder that causes the growth of numerous cysts in the kidneys, leading to a decline in kidney function and various complications. This chapter focuses on the medical management of PKD, highlighting the importance of managing kidney function, controlling hypertension, and using appropriate medications. The role of medications like ACE inhibitors and tolvaptan is highlighted. This chapter also explores advanced treatment options for PKD, including dialysis, and kidney transplantation. Dialysis is necessary when kidney function declines significantly, with hemodialysis and peritoneal dialysis being the primary types. Kidney transplantation offers a more permanent solution by replacing a damaged kidney with a healthy one from a donor. </p> <p><em><strong>Cite as:</strong></em> Treatment and Management of Polycystic Kidney Disease. In: Polycystic Kidney Disease: Public Education. Brisbane (AU): Exon Publications, 2024. Online first 2024 May 26. ISBN: 978-0-6458663-8-4<br>DOI: https://doi.org/10.36255/treatment-management-polycystic-kidney-disease</p> 2024-05-28T00:00:00+10:00 Copyright (c) 2024 Exon Publications https://exonpublications.com/index.php/exon/article/view/glossary-of-terms-polycystic-kidney-disease Glossary of Terms: Polycystic Kidney Disease 2024-05-28T17:28:59+10:00 Glossary of Terms: Polycystic Kidney Disease books@exonpublications.com <p><strong>ACE Inhibitors:</strong> Medications that help relax blood vessels and reduce blood pressure, commonly used to treat hypertension in PKD patients.</p> <p><strong>Angiotensin II Receptor Blockers (ARBs):</strong> Medications that block the action of angiotensin II, a substance that narrows blood vessels, thereby lowering blood pressure.</p> <p><strong>Autosomal Dominant Polycystic Kidney Disease (ADPKD):</strong> The most common form of PKD, inherited in an autosomal dominant pattern, where cysts form in the kidneys and other organs.</p> <p><strong>Autosomal Recessive Polycystic Kidney Disease (ARPKD):</strong> A rarer form of PKD inherited in an autosomal recessive pattern, usually affecting infants and young children.</p> <p><strong>Blood Urea Nitrogen (BUN):</strong> A waste product in the blood that is measured to assess kidney function.</p> <p><strong>Chronic Kidney Disease (CKD):</strong> A long-term condition where the kidneys do not work effectively, often resulting from PKD.</p> <p><strong>Computed Tomography (CT) Scan:</strong> An imaging method that uses X-rays to create detailed cross-sectional images of the body, used to visualize kidney cysts in PKD.</p> <p><strong>Continuous Ambulatory Peritoneal Dialysis (CAPD):</strong> A type of peritoneal dialysis that is done manually by the patient throughout the day.</p> <p><strong>Creatinine:</strong> A waste product from muscle metabolism that is measured in the blood to assess kidney function.</p> <p><strong>Cysts:</strong> Fluid-filled sacs that form in the kidneys and other organs in individuals with PKD.</p> <p><strong>Deceased Donor Transplant:</strong> A kidney transplant from a person who has recently died and whose family has consented to organ donation.</p> <p><strong>Dialysate: </strong>A sterile solution used in peritoneal dialysis to draw waste products and excess fluids from the blood.</p> <p><strong>Dialysis:</strong> A treatment that removes waste products and excess fluids from the blood when the kidneys can no longer perform these functions.</p> <p><strong>End-Stage Renal Disease (ESRD):</strong> The final stage of chronic kidney disease, where the kidneys are no longer able to function properly, requiring dialysis or a kidney transplant.</p> <p><strong>Fistula:</strong> A surgically created connection between an artery and a vein, used to provide access for hemodialysis.</p> <p><strong>Hemodialysis:</strong> A type of dialysis where blood is filtered outside the body using a machine called a dialyzer.</p> <p><strong>Hypertension:</strong> High blood pressure, a common symptom and complication of PKD.</p> <p><strong>Immunosuppressive Medications:</strong> Drugs that suppress the immune system to prevent rejection of a transplanted kidney.</p> <p><strong>Kidney Transplantation:</strong> A surgical procedure that replaces a damaged kidney with a healthy one from a donor.</p> <p><strong>Living Donor Transplant:</strong> A kidney transplant from a living person, usually a family member or friend.</p> <p><strong>Magnetic Resonance Imaging (MRI):</strong> An imaging technique that uses magnetic fields and radio waves to create detailed images of the body, used to assess kidney cysts in PKD.</p> <p><strong>mTOR Pathway:</strong> A cellular pathway involved in cell growth and proliferation, targeted by certain drugs to reduce cyst growth in PKD.</p> <p><strong>Peritoneal Dialysis:</strong> A type of dialysis that uses the lining of the abdomen to filter waste products and excess fluids from the blood.</p> <p><strong>Polycystin:</strong> Proteins produced by the PKD1 and PKD2 genes, mutations in which cause cyst formation in PKD.</p> <p><strong>Renal Function:</strong> The ability of the kidneys to filter waste products and maintain fluid and electrolyte balance in the body.</p> <p><strong>Tolvaptan:</strong> A medication that slows the growth of kidney cysts and preserves kidney function in individuals with ADPKD.</p> <p><strong>Ultrasound:</strong> An imaging technique that uses sound waves to create pictures of the inside of the body, commonly used to detect kidney cysts in PKD.</p> <p><strong>Urinary Tract Infections (UTIs):</strong> Infections of the urinary system, which are common in individuals with PKD due to cysts and other complications.</p> <p><strong>Vasopressin:</strong> A hormone that regulates water balance in the body, targeted by the drug tolvaptan to reduce cyst growth in PKD.</p> <p>DOI: <a href="https://doi.org/10.36255/glossary-of-terms-polycystic-kidney-disease">https://doi.org/10.36255/glossary-of-terms-polycystic-kidney-disease</a></p> 2024-05-28T11:04:05+10:00 Copyright (c) 2024 Exon Publications