The Role of Cathepsin B in Ischemia-Reperfusion Injury After Stroke Book Title: Cerebral Ischemia; ISBN: 978-0-6450017-9-2

Main Article Content

Bhakta Prasad Gaire, PHD
Lalita Subedi, PHD
Hironori Teramoto, BSC
Bingren Hu, PHD

ABSTRACT


Cathepsins are endolysosomal proteases that can be categorized into different types based on their structures and active-site amino acid residue, including cysteine (cathepsins B, C, F, H, K, L, O, S, V, W, and X), serine (cathepsins A and G), and aspartic (cathepsins D and E). Cathepsins can regulate diverse cellular activities such as the processing and presentation of antigens, the processing and activation of hormones, apoptosis, aging, and autophagy. Recently, cathepsin B has gained attention for its role in various neurological diseases including ischemic stroke, Alzheimer’s disease, Parkinson’s disease, and traumatic brain injury. This chapter mainly focuses on the role of cathepsin B in brain ischemia-reperfusion injury in animal models of stroke.

Downloads

Download data is not yet available.

Metrics

Metrics Loading ...

Article Details

Section
Accepted Chapters